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nanoparticle morphology  (Hitachi Ltd)


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    Structured Review

    Hitachi Ltd nanoparticle morphology
    Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging <t>nanoparticles</t> loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.
    Nanoparticle Morphology, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 99/100, based on 42492 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nanoparticle morphology/product/Hitachi Ltd
    Average 99 stars, based on 42492 article reviews
    nanoparticle morphology - by Bioz Stars, 2026-02
    99/100 stars

    Images

    1) Product Images from "ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum–Mitochondrial signaling cascade"

    Article Title: ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum–Mitochondrial signaling cascade

    Journal: Bioactive Materials

    doi: 10.1016/j.bioactmat.2025.12.016

    Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging nanoparticles loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.
    Figure Legend Snippet: Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging nanoparticles loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.

    Techniques Used: In Vivo

    Characterization and ROS-responsiveness of PBHB@Tec. (a) Schematic illustration of the preparation of PBHB@Tec nanoparticles and their ROS-triggered degradation as well as Tec release. (b) DLS analysis showing the size distribution of PBHB and PBHB@Tec nanoparticles. (c) Zeta potential measurements of PBHB and PBHB@Tec. (d) TEM images of PBHB and PBHB@Tec nanoparticles. Scale bar: 500 nm. (e) XPS spectra indicating the chemical composition of PBHB@Tec. (f, g) In vitro ABTS radical scavenging activity and H 2 O 2 clearance ability of PBHB and PBHB@Tec at various concentrations. (h) Cumulative release profiles of Tec from PBHB@Tec nanoparticles in the absence and presence of H 2 O 2 . (i) TEM images of PB, PB incubated with H 2 O 2 , PBHB@Tec, and PBHB@Tec incubated with H 2 O 2 to visualize nanoparticle stability and ROS-triggered degradation. Scale bar: 500 nm. Data are expressed as mean ± SD (n = 3).
    Figure Legend Snippet: Characterization and ROS-responsiveness of PBHB@Tec. (a) Schematic illustration of the preparation of PBHB@Tec nanoparticles and their ROS-triggered degradation as well as Tec release. (b) DLS analysis showing the size distribution of PBHB and PBHB@Tec nanoparticles. (c) Zeta potential measurements of PBHB and PBHB@Tec. (d) TEM images of PBHB and PBHB@Tec nanoparticles. Scale bar: 500 nm. (e) XPS spectra indicating the chemical composition of PBHB@Tec. (f, g) In vitro ABTS radical scavenging activity and H 2 O 2 clearance ability of PBHB and PBHB@Tec at various concentrations. (h) Cumulative release profiles of Tec from PBHB@Tec nanoparticles in the absence and presence of H 2 O 2 . (i) TEM images of PB, PB incubated with H 2 O 2 , PBHB@Tec, and PBHB@Tec incubated with H 2 O 2 to visualize nanoparticle stability and ROS-triggered degradation. Scale bar: 500 nm. Data are expressed as mean ± SD (n = 3).

    Techniques Used: Zeta Potential Analyzer, In Vitro, Activity Assay, Incubation



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    Image Search Results


    Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging nanoparticles loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.

    Journal: Bioactive Materials

    Article Title: ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum–Mitochondrial signaling cascade

    doi: 10.1016/j.bioactmat.2025.12.016

    Figure Lengend Snippet: Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging nanoparticles loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.

    Article Snippet: Nanoparticle morphology was examined by TEM (HT7700, Hitachi), and the elemental composition was determined by XPS (Axis Supra+, Kratos).

    Techniques: In Vivo

    Characterization and ROS-responsiveness of PBHB@Tec. (a) Schematic illustration of the preparation of PBHB@Tec nanoparticles and their ROS-triggered degradation as well as Tec release. (b) DLS analysis showing the size distribution of PBHB and PBHB@Tec nanoparticles. (c) Zeta potential measurements of PBHB and PBHB@Tec. (d) TEM images of PBHB and PBHB@Tec nanoparticles. Scale bar: 500 nm. (e) XPS spectra indicating the chemical composition of PBHB@Tec. (f, g) In vitro ABTS radical scavenging activity and H 2 O 2 clearance ability of PBHB and PBHB@Tec at various concentrations. (h) Cumulative release profiles of Tec from PBHB@Tec nanoparticles in the absence and presence of H 2 O 2 . (i) TEM images of PB, PB incubated with H 2 O 2 , PBHB@Tec, and PBHB@Tec incubated with H 2 O 2 to visualize nanoparticle stability and ROS-triggered degradation. Scale bar: 500 nm. Data are expressed as mean ± SD (n = 3).

    Journal: Bioactive Materials

    Article Title: ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum–Mitochondrial signaling cascade

    doi: 10.1016/j.bioactmat.2025.12.016

    Figure Lengend Snippet: Characterization and ROS-responsiveness of PBHB@Tec. (a) Schematic illustration of the preparation of PBHB@Tec nanoparticles and their ROS-triggered degradation as well as Tec release. (b) DLS analysis showing the size distribution of PBHB and PBHB@Tec nanoparticles. (c) Zeta potential measurements of PBHB and PBHB@Tec. (d) TEM images of PBHB and PBHB@Tec nanoparticles. Scale bar: 500 nm. (e) XPS spectra indicating the chemical composition of PBHB@Tec. (f, g) In vitro ABTS radical scavenging activity and H 2 O 2 clearance ability of PBHB and PBHB@Tec at various concentrations. (h) Cumulative release profiles of Tec from PBHB@Tec nanoparticles in the absence and presence of H 2 O 2 . (i) TEM images of PB, PB incubated with H 2 O 2 , PBHB@Tec, and PBHB@Tec incubated with H 2 O 2 to visualize nanoparticle stability and ROS-triggered degradation. Scale bar: 500 nm. Data are expressed as mean ± SD (n = 3).

    Article Snippet: Nanoparticle morphology was examined by TEM (HT7700, Hitachi), and the elemental composition was determined by XPS (Axis Supra+, Kratos).

    Techniques: Zeta Potential Analyzer, In Vitro, Activity Assay, Incubation